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KMID : 0370220190630060341
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Yakhak Hoeji
2019 Volume.63 No. 6 p.341 ~ p.350
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Analysis of Prescription Patterns for Rheumatoid Arthritis in Korea
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Kim Yoon-Sook
Chun Pu-Soon
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Abstract
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This study was conducted to analyze the prescription patterns of glucocorticoids and disease-modifyingantirheumatic drugs (DMARDs) in the management of rheumatoid arthritis. A cross-sectional study was conducted usingthe claims data of the Health Insurance Review and Assessment Service-National Patient Samples-2016. A total of 4,147patients were analyzed. About 38, 28, and 6% received triamcinolone, methylprednisolone, and hydrocortisone, whereas 65,45, 30, and 20% received methotrexate, hydroxychloroquine, leflunomide, and sulfasalazine. A total of 369 patients receivedbiological DMARDs and approximately 47% received tocilizumab or adalimumab. Most of the biological DMARDs wereconcurrently prescribed with synthetic DMARD, especially methotrexate. In case of injectable glucocorticoids, 84% of therepeated injections were given within 12 weeks after the previous injections. As for oral glucocorticoid cases, 48% were“low dose” and stopped within 3 months. Furthermore, 15% continued for more than 6 months and 20% were prescribedat high doses. This study found that the prescription patterns of DMARDs met with the guidelines of American Collegeof Rheumatology (ACR) and European League Against Rheumatism (EULAR). However, in many cases of glucocorticoiduses, the dose was higher and the duration was longer than the recommendations of the guidelines. High doses and longtermuse of glucocorticoids should be restrained to prevent serious side effects.
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KEYWORD
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Disease-modifying antirheumatic drugs, glucocorticoids, prescription patterns, rheumatoid arthritis
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